Përcaktimi i disa antibiotikëve në mostra uji me anë të HPLC/DAD
DOI:
https://doi.org/10.55312/op.vi2.4519Abstract
Qëllimi i këtij studimi është të paraqesë një metodë analitike për përcaktimin e antibiotikëve në mostrat e ujit të pijshëm në qytetin e Tiranës dhe të lumenjve të Lanës dhe Tiranës. Përcaktimi i antibiotikëve në mostrat e ujit është një analizë e rëndësishme për shkak të përdorimeve të shumta të antibiotikëve në trajtimet mjekësore. Prania e tyre në ujëra ka sjellë në përgjithësi uljen e forcës së tyre vepruese për shkak të emisioneve të vazhdueshme të njerëzve me sasi të vogla të antibiotikëve. Kjo sjell përshtatjen e mikrobeve ndaj tyre (1; 2; 3; 4; 5).Keywords:
antibiotikë, HPLC/DAD, SPE, mostra uji.Downloads
References
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Birosova, L., Mackulak, T., Bodik, I., Ryba, J., Skubak, J. & Grabic, R. 2014: Pilot study of seasonal occurrence and distribution of antibiotics and drug resistant bacteria in wastewater treatment plants in Slovakia. Science of the Total Environment 490, 440–444.
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Chambers, E., Wagrowski-Diehl, D. M., Lu, Z. & Mazzeo, J. R. 2007: Systematic and comprehensive strategy for reducing matrix eff ects in LC/MS/MS analyses. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 852 (1–2), 22-34.
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Jia A., Xiao Y., Hu J., Asami M., Kunikane S.: Simultaneous determination of tetracyclines and their degradation products in environmental waters by liquid chromatography-electrospray tandem mass spectrometry. J Chromatogr A 2009, 1216, 4655–4662.
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Babić S., Asperger D., Mutavdzić D., Horvat A.J.M., Kastelan–Macan M.: Solid phase extraction and HPLC determination of 70 E. Patyra et al./Bull Vet Inst Pulawy/58 (2014) 65-70 veterinary pharmaceuticals in wastewater. Talanta 2006, 70, 732–738.
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Hao, C., Zhao, X. & Yang, P. 2007: GCMS and HPLC-MS analysis of bioactive pharmaceuticals and personal-care products in environmental matrices. TrAC trends in Analytical Chemistry 26 (6), 569–580.
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Jain, S., Kumar, P., Vyas, R. K., Pandit, P. & Dalai, A. K. 2013: Occurrence and Removal of Antiviral Drugs in Environment: A Review. Water Air and Soil Pollution 224 (2), 1410.
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Karthikeyan, K. G. & Meyer, M. T. 2006: Occurrence of antibiotics in wastewater treatment facilities in Wisconsin, USA. Science of the Total Environment 361 (1–3), 196–207.
-
Rao, R. N., Venkateswarlu, N. & Narsimha, R. 2008: Determination of antibiotics in aquatic environment by solid-phase extraction followed by
-
liquid chromatography-electrospray ionization mass spectrometry. Journal of chromatography a 1187 (1-2), 151–164.
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Kümmerer, K. 2009: Antibiotics in the aquatic environment - A review - Part II. Chemosphere 75 (4), 435–441.
-
Samanidou, V. & Karageorgou, E. 2010: Drug Monitoring by HPLC: RecentM Developments. New York, Nova Science.
-
Seifrtova, M., Novakova, L., Lino, C., Pena, A. & Solich, P. 2009: An overview of analytical methodologies for the determination of antibiotics in environmental waters. Analytica Chimica Acta 649 (2), 158–179.
-
Cinquina A. L., Longo F., Anastasi G., Giannetti L., CozzaniR.: Validation of a high-performance liquid chromatography method for the determinati on of oxytetracycline, tetracycline, chlorotetracycline and doxycycline in
-
bovine milk and muscle. J Chromatogr A 2003, 987, 227–233.
-
Cooper A.D., Stubbings G.W.F., Hirsch R., Terens T.A., Haberer K., Mehlich A., Ballwanz F., Monser L., Darghouth F.: Rapid liquid chromatographic method for simultaneous determination of tetracyclines antibiotics an 6-Epi-doxycycline in pharmaceutical products using porous graphitic carbon column. J Pharm Biomed Anal 2000, 23, 353–362.
References
Birosova, L., Mackulak, T., Bodik, I., Ryba, J., Skubak, J. & Grabic, R. 2014: Pilot study of seasonal occurrence and distribution of antibiotics and drug resistant bacteria in wastewater treatment plants in Slovakia. Science of the Total Environment 490, 440–444.
Chambers, E., Wagrowski-Diehl, D. M., Lu, Z. & Mazzeo, J. R. 2007: Systematic and comprehensive strategy for reducing matrix eff ects in LC/MS/MS analyses. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 852 (1–2), 22-34.
Jia A., Xiao Y., Hu J., Asami M., Kunikane S.: Simultaneous determination of tetracyclines and their degradation products in environmental waters by liquid chromatography-electrospray tandem mass spectrometry. J Chromatogr A 2009, 1216, 4655–4662.
Babić S., Asperger D., Mutavdzić D., Horvat A.J.M., Kastelan–Macan M.: Solid phase extraction and HPLC determination of 70 E. Patyra et al./Bull Vet Inst Pulawy/58 (2014) 65-70 veterinary pharmaceuticals in wastewater. Talanta 2006, 70, 732–738.
Hao, C., Zhao, X. & Yang, P. 2007: GCMS and HPLC-MS analysis of bioactive pharmaceuticals and personal-care products in environmental matrices. TrAC trends in Analytical Chemistry 26 (6), 569–580.
Jain, S., Kumar, P., Vyas, R. K., Pandit, P. & Dalai, A. K. 2013: Occurrence and Removal of Antiviral Drugs in Environment: A Review. Water Air and Soil Pollution 224 (2), 1410.
Karthikeyan, K. G. & Meyer, M. T. 2006: Occurrence of antibiotics in wastewater treatment facilities in Wisconsin, USA. Science of the Total Environment 361 (1–3), 196–207.
Rao, R. N., Venkateswarlu, N. & Narsimha, R. 2008: Determination of antibiotics in aquatic environment by solid-phase extraction followed by
liquid chromatography-electrospray ionization mass spectrometry. Journal of chromatography a 1187 (1-2), 151–164.
Kümmerer, K. 2009: Antibiotics in the aquatic environment - A review - Part II. Chemosphere 75 (4), 435–441.
Samanidou, V. & Karageorgou, E. 2010: Drug Monitoring by HPLC: RecentM Developments. New York, Nova Science.
Seifrtova, M., Novakova, L., Lino, C., Pena, A. & Solich, P. 2009: An overview of analytical methodologies for the determination of antibiotics in environmental waters. Analytica Chimica Acta 649 (2), 158–179.
Cinquina A. L., Longo F., Anastasi G., Giannetti L., CozzaniR.: Validation of a high-performance liquid chromatography method for the determinati on of oxytetracycline, tetracycline, chlorotetracycline and doxycycline in
bovine milk and muscle. J Chromatogr A 2003, 987, 227–233.
Cooper A.D., Stubbings G.W.F., Hirsch R., Terens T.A., Haberer K., Mehlich A., Ballwanz F., Monser L., Darghouth F.: Rapid liquid chromatographic method for simultaneous determination of tetracyclines antibiotics an 6-Epi-doxycycline in pharmaceutical products using porous graphitic carbon column. J Pharm Biomed Anal 2000, 23, 353–362.
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