Roli i antioxidantëve në menazhimin e faktorëve proatherogjen dhe protrombotik
Abstrakti
Sëmundja e arterieve koronare që njihet ndryshe edhe si sëmundje ishemike e zemrës është shkaktari kryesor i vdekjeve në ditët e sotëshme në vendet e zhvilluara. Qëllimi i këtij studimi është që të ofrojë udhëzime parandaluese bazuara në evidencat e fundit mbi rëndësinë e antioksidantëve natyrore tek pacientët me patologji koronare përmes monitorimit të vlerave të trimetilaminëoxidazës (TMAO), metabolitit pro-atherogjen e protrombotik, të Low density lipoprotein (LDL-së), Proteinës C-Reaktive (PCR-së) duke testuar in vivo efikasitetin e një nutraceutiku me bazë ekstraktet polifenolike të resveratrolit përgatitur nga bërsitë e rrushit (Vitis vinifera L.)
Fjalët kyçe:
patologji koronare, trimetilamineoxidave, resveratrol, produkte natyrale, antioksidant.Shkarkimet
References
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Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, et al. Heart disease and stroke statistics’2017 update: a report from the American Heart Association. Circulation. (2017) 135:e146–603. doi: 10.1161/CIR.0000000000000485
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Zhu Y, Li Q, Jiang H. Gut microbiota in atherosclerosis: focus on trimethylamine N-oxide. APMIS. (2020) 128:353–66. doi: 10.1111/apm.13038
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Shi X, He J, Lin M, Liu C, Yan B, Song H, et al. Comparative effectiveness of team-based care with a clinical decision support system versus team-based care alone on cardiovascular risk reduction among patients with diabetes: Rationale and design of the D4C trial. Am Heart
-
J. (2021) 238:45–58. doi: 10.1016/j.ahj.2021.04.009
-
Kaze AD, Santhanam P, Musani SK, Ahima R, Echouffo-Tcheugui JB. Metabolic dyslipidemia and cardiovascular outcomes in type 2 diabetes mellitus: findings from the look AHEAD study. J Am Heart Assoc. (2021) 10:e016947. doi: 10.1161/JAHA.120.016947
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Rostomian AH, Tang MC, Soverow J, Sanchez DR. Heterogeneity of treatment effect in SPRINT by age and baseline comorbidities: The greatest impact of intensive blood pressure treatment is observed among younger patients without CKD or CVD and in older patients with CKD or
-
CVD. J Clin Hypertens (Greenwich). (2020) 22:1723–6. doi: 10.1111/jch.13955
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Tang WH, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med. (2013) 368:1575–84. doi:10.1056/NEJMoa1109400
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Zhang Y, Wang Y, Ke B and Du J (2021) TMAO: how gut microbiota contributes to heart failure. Transl Res 228, 109–125
-
Annunziata G, Maisto M, Schisano C, Ciampaglia R, Narciso V, Hassan STS, et al. Effect of grape pomace polyphenols with or without pectin on TMAO serum levels assessed by LC/MS-based assay: a preliminary clinical study on overweight/obese subjects. Front Pharmacol.
-
(2019) 10:575. doi: 10.3389/fphar.2019.00575
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Ivashkin V, Kashukh YA. Impact of L-carnitine and phosphatidylcholine containing products on the proatherogenic metabolite TMAO production and gut microbiome changes in patients with coronary artery disease. Vopr Pitan. (2019) 88:25–33. doi: 10.24411/0042-8833-2019-10038
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Pignatelli P, Menichelli D, Pastori D, Violi F. Oxidative stress and cardiovascular disease: new insights. Kardiol Pol. (2018) 76:713–722. doi: 10.5603/KP.a2018.007
References
Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, et al. Heart disease and stroke statistics’2017 update: a report from the American Heart Association. Circulation. (2017) 135:e146–603. doi: 10.1161/CIR.0000000000000485
Zhu Y, Li Q, Jiang H. Gut microbiota in atherosclerosis: focus on trimethylamine N-oxide. APMIS. (2020) 128:353–66. doi: 10.1111/apm.13038
Shi X, He J, Lin M, Liu C, Yan B, Song H, et al. Comparative effectiveness of team-based care with a clinical decision support system versus team-based care alone on cardiovascular risk reduction among patients with diabetes: Rationale and design of the D4C trial. Am Heart
J. (2021) 238:45–58. doi: 10.1016/j.ahj.2021.04.009
Kaze AD, Santhanam P, Musani SK, Ahima R, Echouffo-Tcheugui JB. Metabolic dyslipidemia and cardiovascular outcomes in type 2 diabetes mellitus: findings from the look AHEAD study. J Am Heart Assoc. (2021) 10:e016947. doi: 10.1161/JAHA.120.016947
Rostomian AH, Tang MC, Soverow J, Sanchez DR. Heterogeneity of treatment effect in SPRINT by age and baseline comorbidities: The greatest impact of intensive blood pressure treatment is observed among younger patients without CKD or CVD and in older patients with CKD or
CVD. J Clin Hypertens (Greenwich). (2020) 22:1723–6. doi: 10.1111/jch.13955
Tang WH, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med. (2013) 368:1575–84. doi:10.1056/NEJMoa1109400
Zhang Y, Wang Y, Ke B and Du J (2021) TMAO: how gut microbiota contributes to heart failure. Transl Res 228, 109–125
Annunziata G, Maisto M, Schisano C, Ciampaglia R, Narciso V, Hassan STS, et al. Effect of grape pomace polyphenols with or without pectin on TMAO serum levels assessed by LC/MS-based assay: a preliminary clinical study on overweight/obese subjects. Front Pharmacol.
(2019) 10:575. doi: 10.3389/fphar.2019.00575
Ivashkin V, Kashukh YA. Impact of L-carnitine and phosphatidylcholine containing products on the proatherogenic metabolite TMAO production and gut microbiome changes in patients with coronary artery disease. Vopr Pitan. (2019) 88:25–33. doi: 10.24411/0042-8833-2019-10038
Pignatelli P, Menichelli D, Pastori D, Violi F. Oxidative stress and cardiovascular disease: new insights. Kardiol Pol. (2018) 76:713–722. doi: 10.5603/KP.a2018.007