Rëndësia e elementeve kobalt, krom, selen dhe molibden (gjurmë) në shëndetin oral
DOI:
https://doi.org/10.55312/op.vi2.6079Abstract
Elementet gjurmë, të rëndësishme si mikronutriente kimike, gjenden në ambiente natyrore dhe të ndryshuara në koncentracione të vogla. Ndërsa janë thelbësorë për funksione të ndryshme biologjike, sasi të tepruara të këtyre elementeve mund të jenë toksike për organizmat. Ky rishikim thekson rolet e elementeve kritike gjurmë—përfshirë kobalt, krom, selen dhe molibden—në proceset fisiologjike dhe shëndetin oral. Kobalti, i integruar në vitaminën B12, është i rëndësishëm për formimin e eritrociteve dhe funksionin neurologjik, me mungesat që çojnë në anemi dhe probleme të mundshme në shëndetin oral si glossiti. Kromi kontribuon në metabolizmin e glukozës, dhe mungesa e tij mund të përkeqësojë komplikacionet orale te pacientët diabetikë. Seleni shërben si një komponent thelbësor i enzimave antioksiduese, me mungesën e tij të lidhur me rritjen e stresit oksidativ, veçanërisht në kanceret orale dhe lezionet premalignante. Molibdeni, i njohur për rolin e tij në funksionin e enzimave, mund të ketë prona kariostatik, megjithëse provat mbeten të paqartë. Në përgjithësi, balanct e elementeve gjurmë—paqendim nga mangësitë ose tepricat toksike—theksin rëndësinë e tyre në ruajtjen e shëndetit të përgjithshëm dhe oral.
Keywords:
Kobalt , Selen, Krom, Molybden, Shëndet oralDownloads
References
-
Chapple I. L., Brock G. R., Milward M. R., Ling N., Matthews J. B. Compromised GCF total antioxidant capacity in periodontitis: cause or effect? Journal of Clinical Periodontology. 2007;34(2):103–110. doi: 10.1111/j.1600-051x.2006.01029.x. [DOI] [PubMed] [Google Scholar]
-
Moynihan P. J. The role of diet and nutrition in the etiology and prevention of oral diseases. Bulletin of the World Health Organization. 2005;83(9):694–699. [PMC free article] [PubMed] [Google Scholar]
-
Chen M., Andersen R. M., Barmes D. E., Leclerq M. H., Little S. V. Comparing Oral Health Systems: A Second International Collaborative Study. Geneva, Switzerland: World Health Organization; 1997. [Google Scholar]
-
Wada O. What are trace elements? Their deficiency and excess states. Japan Medical Association Journal. 2004;47(8):351–358. [Google Scholar]
-
WHO. Trace-Elements in Human Nutrition. Report of a WHO Expert Committee. Geneva, Switzerland: World Health Organization; 1973. (WHO Technical Report Series, No. 532). [PubMed] [Google Scholar]
-
Frieden E. New perspectives on the essential trace elements. Journal of Chemical Education. 1985;62(11):915–923. doi: 10.1021/ed062p915. [DOI] [Google Scholar]
-
Rajalalitha P. Molecular pathogenesis of OSMF. Journal of Oral Pathology and Medicine. 2005;34(6):321–328. doi: 10.1111/j.1600-0714.2005.00325.x. [DOI] [PubMed] [Google Scholar]
-
Prashanth L., Kattapagari K. K., Chitturi R. T., Baddam V. R., Prasad L. K. A review on role of essential trace elements in health and disease. Journal of NTR University of Health Sciences. 2015;4:75–85. [Google Scholar]
-
Wapnir R. A. Protein Nutrition and Mineral Absorption. Boca Raton, Fla, USA: CRC Press; 1990. [Google Scholar]
-
Valko M., Morris H., Cronin M. T. D. Metals, toxicity and oxidative stress. Current Medicinal Chemistry. 2005;12(10):1161–1208. doi: 10.2174/0929867053764635. [DOI] [PubMed] [Google Scholar]
-
Sandstead H. H. Understanding zinc: recent observations and interpretations. Journal of Laboratory and Clinical Medicine. 1994;124(3):322–327. [PubMed] [Google Scholar]
-
Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC, USA: National Academy Press; 2001. [PubMed] [Google Scholar]
-
Milbury P. E., Richer A. C. Understanding the Antioxidant Controversy: Scrutinizing the “Fountain of Youth”. Greenwood Publishing Group; 2008. [Google Scholar]
-
Lynch R. J. Zinc in the mouth, its interactions with dental enamel and possible effects on caries; a review of the literature. International Dental Journal. 1984;61(supplement 3):46–54. doi: 10.1111/j.1875-595X.2011.00049.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
-
Satyanarayana U., Chakrapani U. Essentials of Biochemistry. 2nd. Kolkata, India: Book and Allied; 2008. [Google Scholar]
-
Neville B. D., Damm D. D., Allen C. M., Bouquot J. E. Oral and Maxillofacial Pathology. 3rd. Chennai, India: Elsevier; 2009. [Google Scholar]
-
Bhattacharya P. T., Khaitan T., Sarkar S. B., Sinha R. Oral submucous fibrosis secondary to iron deficiency anemia: a case report, etiopathogenesis and management. The Journal of Nutrition, Health and Aging. 2016;20(2):205–208. doi: 10.1007/s12603-015-0578-9. [DOI] [PubMed] [Google Scholar]
-
Barceloux D. G. Cobalt. Journal of Toxicology—Clinical Toxicology. 1999;37(2):201–216. doi: 10.1081/clt-100102420. [DOI] [PubMed] [Google Scholar]
-
Yamagata N., Murata S., Torii T. The cobalt content of human body. Journal of Radiation Research. 1962;3(1):4–8. doi: 10.1269/jrr.3.4. [DOI] [PubMed] [Google Scholar]
-
Taylor N. A., Marks T. S. Food and nutrition board recommended daily allowances. Journal of Human Nutrition and Dietetics. 1974;32:165–177. [Google Scholar]
-
Christensen J. M., Poulsen O. M., Thomsen M. A short-term cross-over study on oral administration of soluble and insoluble cobalt compounds: sex differences in biological levels. International Archives of Occupational and Environmental Health. 1993;65(4):233–240. doi: 10.1007/BF00381196. [DOI] [PubMed] [Google Scholar]
-
Czarnek K., Terpiłowska S., Siwicki A. K. Selected aspects of the action of cobalt ions in the human body. Central European Journal of Immunology. 2015;40(2):236–242. doi: 10.5114/ceji.2015.52837. [DOI] [PMC free article] [PubMed] [Google Scholar]
-
Lombaert N., Lison D., Van Hummelen P., Kirsch-Volders M. In vitro expression of hard metal dust (WC-Co)—responsive genes in human peripheral blood mononucleated cells. Toxicology and Applied Pharmacology. 2008;227(2):299–312. doi: 10.1016/j.taap.2007.11.002. [DOI] [PubMed] [Google Scholar]
-
Shafer W. G., Hine M. K., Levy B. M. A Textbook of Oral Pathology. 4th. Chennai, India: Elsevier India; 2004. [Google Scholar]
-
Ismail S. B., Kumar S. K. S., Zain R. B. Oral lichen planus and lichenoid reactions: etiopathogenesis, diagnosis, management and malignant transformation. Journal of Oral Science. 2007;49(2):89–106. doi: 10.2334/josnusd.49.89. [DOI] [PubMed] [Google Scholar]
-
Krejpcio Z. Essentiality of chromium for human nutrition and health. Polish Journal of Environmental Studies. 2001;10(6):399–404. [Google Scholar]
-
Nguta J. M. Essential Trace Elements: Trace Elements in Human and Animal Health. Saarbrücken, Germany: LAP, Lambert Academic Publishing; 2010. [Google Scholar]
-
Kulkarni N., Kalele K., Kulkarni M., Kathariya R. Trace elements in oral health and disease: an updated review. Journal of Dental Research and Review. 2014;1(2):100–104. doi: 10.4103/2348-2915.133959. [DOI] [Google Scholar]
-
Rayman M. P. Selenium and human health. The Lancet. 2012;379(9822):1256–1268. doi: 10.1016/S0140-6736(11)61452-9. [DOI] [PubMed] [Google Scholar]
-
Serwin A. B., Wasowicz W., Gromadzinska J., Chodynicka B. Selenium status in psoriasis and its relations to the duration and severity of the disease. Nutrition. 2003;19(4):301–304. doi: 10.1016/S0899-9007(02)01081-X. [DOI] [PubMed] [Google Scholar]
-
Arthur J. R., Beckett G. R. Selenium deficiency and thyroid hormone metabolism. In: Wendell A., editor. Selenium in Biology and Medicine. Berlin, Germany: Springer; 1989. pp. 90–95. [Google Scholar]
-
Contempre B., Dumont J. E., Ngo B., Thilly C. H., Diplock A. T., Vanderpas J. Effect of selenium supplementation in hypothyroid subjects of an iodine and selenium deficient area: the possible danger of indiscriminate supplementation of iodine-deficient subjects with selenium. Journal of Clinical Endocrinology and Metabolism. 1991;73(1):213–215. doi: 10.1210/jcem-73-1-213. [DOI] [PubMed] [Google Scholar]
-
Swain N., Ray J. G. Altered trace element level and antioxidant activity in whole blood of oral leukoplakia and cancer patients in comparison with healthy controls. International Journal of Oral & Maxillofacial Pathology. 2011;2(2):2–6. [Google Scholar]
-
Jahangard-Rafsanjani Z., Gholami K., Hadjibabaie M., et al. The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial. Bone Marrow Transplantation. 2013;48(6):832–836. doi: 10.1038/bmt.2012.250. [DOI] [PubMed] [Google Scholar]
-
Coughlan M. P. The role of molybdenum in human biology. Journal of Inherited Metabolic Disease. 1983;6(supplement 1):70–77. doi: 10.1007/bf01811327. [DOI] [PubMed] [Google Scholar]
-
Suttle N. F. Recent studies of the copper-molybdenum antagonism. Proceedings of the Nutrition Society. 1974;33(3):299–305. doi: 10.1079/pns19740053. [DOI] [PubMed] [Google Scholar]
-
Curzon M., Kubota J., Bibby B. Environmental effects of molybdenum on caries. Journal of Dental Research. 1971;50(1):74–77. doi: 10.1177/00220345710500013401. [DOI] [Google Scholar]
-
Venturi S., Venturi M. Iodine in evolution of salivary glands and in oral health. Nutrition and Health. 2009;20(2):119–134. doi: 10.1177/026010600902000204. [DOI] [PubMed] [Google Scholar]
-
Greenberg M. S., Glick M., Ship J. A. Burket’s Oral Medicine. 11th. New Delhi, India: CBS Publisher; 2008. [Google Scholar]
-
Brugnara C. Iron deficiency and erythropoiesis: new diagnostic approaches. Clinical Chemistry. 2003;49(10):1573–1578. doi: 10.1373/49.10.1573. [DOI] [PubMed] [Google Scholar]
-
Park K. Park’s Textbook of Preventive and Social Medicine. 21st. Jabalpur, India: Banarsidas Bhanot; 2011. [Google Scholar]
References
Chapple I. L., Brock G. R., Milward M. R., Ling N., Matthews J. B. Compromised GCF total antioxidant capacity in periodontitis: cause or effect? Journal of Clinical Periodontology. 2007;34(2):103–110. doi: 10.1111/j.1600-051x.2006.01029.x. [DOI] [PubMed] [Google Scholar]
Moynihan P. J. The role of diet and nutrition in the etiology and prevention of oral diseases. Bulletin of the World Health Organization. 2005;83(9):694–699. [PMC free article] [PubMed] [Google Scholar]
Chen M., Andersen R. M., Barmes D. E., Leclerq M. H., Little S. V. Comparing Oral Health Systems: A Second International Collaborative Study. Geneva, Switzerland: World Health Organization; 1997. [Google Scholar]
Wada O. What are trace elements? Their deficiency and excess states. Japan Medical Association Journal. 2004;47(8):351–358. [Google Scholar]
WHO. Trace-Elements in Human Nutrition. Report of a WHO Expert Committee. Geneva, Switzerland: World Health Organization; 1973. (WHO Technical Report Series, No. 532). [PubMed] [Google Scholar]
Frieden E. New perspectives on the essential trace elements. Journal of Chemical Education. 1985;62(11):915–923. doi: 10.1021/ed062p915. [DOI] [Google Scholar]
Rajalalitha P. Molecular pathogenesis of OSMF. Journal of Oral Pathology and Medicine. 2005;34(6):321–328. doi: 10.1111/j.1600-0714.2005.00325.x. [DOI] [PubMed] [Google Scholar]
Prashanth L., Kattapagari K. K., Chitturi R. T., Baddam V. R., Prasad L. K. A review on role of essential trace elements in health and disease. Journal of NTR University of Health Sciences. 2015;4:75–85. [Google Scholar]
Wapnir R. A. Protein Nutrition and Mineral Absorption. Boca Raton, Fla, USA: CRC Press; 1990. [Google Scholar]
Valko M., Morris H., Cronin M. T. D. Metals, toxicity and oxidative stress. Current Medicinal Chemistry. 2005;12(10):1161–1208. doi: 10.2174/0929867053764635. [DOI] [PubMed] [Google Scholar]
Sandstead H. H. Understanding zinc: recent observations and interpretations. Journal of Laboratory and Clinical Medicine. 1994;124(3):322–327. [PubMed] [Google Scholar]
Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC, USA: National Academy Press; 2001. [PubMed] [Google Scholar]
Milbury P. E., Richer A. C. Understanding the Antioxidant Controversy: Scrutinizing the “Fountain of Youth”. Greenwood Publishing Group; 2008. [Google Scholar]
Lynch R. J. Zinc in the mouth, its interactions with dental enamel and possible effects on caries; a review of the literature. International Dental Journal. 1984;61(supplement 3):46–54. doi: 10.1111/j.1875-595X.2011.00049.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
Satyanarayana U., Chakrapani U. Essentials of Biochemistry. 2nd. Kolkata, India: Book and Allied; 2008. [Google Scholar]
Neville B. D., Damm D. D., Allen C. M., Bouquot J. E. Oral and Maxillofacial Pathology. 3rd. Chennai, India: Elsevier; 2009. [Google Scholar]
Bhattacharya P. T., Khaitan T., Sarkar S. B., Sinha R. Oral submucous fibrosis secondary to iron deficiency anemia: a case report, etiopathogenesis and management. The Journal of Nutrition, Health and Aging. 2016;20(2):205–208. doi: 10.1007/s12603-015-0578-9. [DOI] [PubMed] [Google Scholar]
Barceloux D. G. Cobalt. Journal of Toxicology—Clinical Toxicology. 1999;37(2):201–216. doi: 10.1081/clt-100102420. [DOI] [PubMed] [Google Scholar]
Yamagata N., Murata S., Torii T. The cobalt content of human body. Journal of Radiation Research. 1962;3(1):4–8. doi: 10.1269/jrr.3.4. [DOI] [PubMed] [Google Scholar]
Taylor N. A., Marks T. S. Food and nutrition board recommended daily allowances. Journal of Human Nutrition and Dietetics. 1974;32:165–177. [Google Scholar]
Christensen J. M., Poulsen O. M., Thomsen M. A short-term cross-over study on oral administration of soluble and insoluble cobalt compounds: sex differences in biological levels. International Archives of Occupational and Environmental Health. 1993;65(4):233–240. doi: 10.1007/BF00381196. [DOI] [PubMed] [Google Scholar]
Czarnek K., Terpiłowska S., Siwicki A. K. Selected aspects of the action of cobalt ions in the human body. Central European Journal of Immunology. 2015;40(2):236–242. doi: 10.5114/ceji.2015.52837. [DOI] [PMC free article] [PubMed] [Google Scholar]
Lombaert N., Lison D., Van Hummelen P., Kirsch-Volders M. In vitro expression of hard metal dust (WC-Co)—responsive genes in human peripheral blood mononucleated cells. Toxicology and Applied Pharmacology. 2008;227(2):299–312. doi: 10.1016/j.taap.2007.11.002. [DOI] [PubMed] [Google Scholar]
Shafer W. G., Hine M. K., Levy B. M. A Textbook of Oral Pathology. 4th. Chennai, India: Elsevier India; 2004. [Google Scholar]
Ismail S. B., Kumar S. K. S., Zain R. B. Oral lichen planus and lichenoid reactions: etiopathogenesis, diagnosis, management and malignant transformation. Journal of Oral Science. 2007;49(2):89–106. doi: 10.2334/josnusd.49.89. [DOI] [PubMed] [Google Scholar]
Krejpcio Z. Essentiality of chromium for human nutrition and health. Polish Journal of Environmental Studies. 2001;10(6):399–404. [Google Scholar]
Nguta J. M. Essential Trace Elements: Trace Elements in Human and Animal Health. Saarbrücken, Germany: LAP, Lambert Academic Publishing; 2010. [Google Scholar]
Kulkarni N., Kalele K., Kulkarni M., Kathariya R. Trace elements in oral health and disease: an updated review. Journal of Dental Research and Review. 2014;1(2):100–104. doi: 10.4103/2348-2915.133959. [DOI] [Google Scholar]
Rayman M. P. Selenium and human health. The Lancet. 2012;379(9822):1256–1268. doi: 10.1016/S0140-6736(11)61452-9. [DOI] [PubMed] [Google Scholar]
Serwin A. B., Wasowicz W., Gromadzinska J., Chodynicka B. Selenium status in psoriasis and its relations to the duration and severity of the disease. Nutrition. 2003;19(4):301–304. doi: 10.1016/S0899-9007(02)01081-X. [DOI] [PubMed] [Google Scholar]
Arthur J. R., Beckett G. R. Selenium deficiency and thyroid hormone metabolism. In: Wendell A., editor. Selenium in Biology and Medicine. Berlin, Germany: Springer; 1989. pp. 90–95. [Google Scholar]
Contempre B., Dumont J. E., Ngo B., Thilly C. H., Diplock A. T., Vanderpas J. Effect of selenium supplementation in hypothyroid subjects of an iodine and selenium deficient area: the possible danger of indiscriminate supplementation of iodine-deficient subjects with selenium. Journal of Clinical Endocrinology and Metabolism. 1991;73(1):213–215. doi: 10.1210/jcem-73-1-213. [DOI] [PubMed] [Google Scholar]
Swain N., Ray J. G. Altered trace element level and antioxidant activity in whole blood of oral leukoplakia and cancer patients in comparison with healthy controls. International Journal of Oral & Maxillofacial Pathology. 2011;2(2):2–6. [Google Scholar]
Jahangard-Rafsanjani Z., Gholami K., Hadjibabaie M., et al. The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial. Bone Marrow Transplantation. 2013;48(6):832–836. doi: 10.1038/bmt.2012.250. [DOI] [PubMed] [Google Scholar]
Coughlan M. P. The role of molybdenum in human biology. Journal of Inherited Metabolic Disease. 1983;6(supplement 1):70–77. doi: 10.1007/bf01811327. [DOI] [PubMed] [Google Scholar]
Suttle N. F. Recent studies of the copper-molybdenum antagonism. Proceedings of the Nutrition Society. 1974;33(3):299–305. doi: 10.1079/pns19740053. [DOI] [PubMed] [Google Scholar]
Curzon M., Kubota J., Bibby B. Environmental effects of molybdenum on caries. Journal of Dental Research. 1971;50(1):74–77. doi: 10.1177/00220345710500013401. [DOI] [Google Scholar]
Venturi S., Venturi M. Iodine in evolution of salivary glands and in oral health. Nutrition and Health. 2009;20(2):119–134. doi: 10.1177/026010600902000204. [DOI] [PubMed] [Google Scholar]
Greenberg M. S., Glick M., Ship J. A. Burket’s Oral Medicine. 11th. New Delhi, India: CBS Publisher; 2008. [Google Scholar]
Brugnara C. Iron deficiency and erythropoiesis: new diagnostic approaches. Clinical Chemistry. 2003;49(10):1573–1578. doi: 10.1373/49.10.1573. [DOI] [PubMed] [Google Scholar]
Park K. Park’s Textbook of Preventive and Social Medicine. 21st. Jabalpur, India: Banarsidas Bhanot; 2011. [Google Scholar]



