Sindroma e vezores policistike - Shkaku kryesor i infertilitetit
DOI:
https://doi.org/10.55312/op.vi2.4583Abstract
Sindroma e vezores policistike (PCOS) është një sëmundje komplekse endokrine dhe renditet si shkaktari i dytë i infertilitetit sipas OBSH. Karakteristikat klinike të PCOS janë heterogjene dhe ndryshojnë duke filluar nga adoleshenca drejt menopauzës. Studime në kafshë sugjerojnë se ekspozimi i androgjenëve gjatë jetës intrauterine bëhet shkas për zhvillimin e PCOS në jetën adulte. Njohja e simptomave të PCOS sa më herët është shumë e rëndësishme për të përcaktuar diagnozën korrekte të PCOS.Keywords:
PCOS, metformin, infertiliteti, sëmundjet metabolike, diagnoza dhe trajtimiDownloads
References
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Stein IF, Leventhal ML. “Amenorrea associated with bilateral polycystic ovaries”. Am J Obstet Gynecol 1935; 29: 181-191.
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Melo AS, Vieira CS, Barbieri MA, RosaE-Silva AC, Silva AA, Cardoso VC, Reis RM, Ferriani RA, Silva-de-Sa MF, & Bettiol H “High prevalence of polycystic ovary syndrome in women born small for gestational age”. Human reproduction 2010; 25: 2124-2131.
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Ehrmann DA. “Polycystic ovary sindrome” N Engl J Med 2005; 352: 1223-36.
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Diamanti-Kandarakis E, Kandarakis H & Legro RS. “ The role of genes and environment in the etiology of PCOS”. Endocrine 2006; 30: 19-26 .
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Gambineri A, Pelusi C, Vicennati V, Pagotto U, Pasquali R. “ Obesity and the polycystic ovary syndrome”. Int J Obes Rel Metab Disord 2002; 26: 883-96.
-
Von Shoultz B, Calstrom K. “ On the regulation of sex-hormone-binding globulin. A challenge of old dogma and outlines of an alternative mechanism”. J Steroid Biochem 1989; 32: 327-34.
-
Dunaif A, Green G, Phelp RG. “Acanthosis Nigricans, insulin action and hyperandrogenism: clinical, histological, and biochemical findings”. J Clin Endocrinol Metab 1991; 73: 590-595.
-
Wild RA, Carmina E, Diamanti-Kandarakis E. “Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the Polycystic Ovary Syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome Society”. J Clin Endocrinol Metab 2010; 95: 2038-2049 .
-
Hardiman P, Pillay OC, Atiomo W. “Polycystic Ovary Syndrome and endometrial carcinoma”. Lancet 2003; 361: 1810-1812.
-
Azziz R, Carmina E, Dewailly D. “The androgjen excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report”. Fertil steril 2009; 91: 456-488.
-
Moran L J, Hutchison SK, Norman RJ, Teede HJ.“ Lifestyle changes in women with polycystic ovary sindrome”. Cochrane Database Syst Rev 2011; 7: CD007506.
-
Mathur R, Levin O, Azziz R. “Use of ethinylestradiol/drospirenone combination n patients with the polycystic ovary syndrome”. Ther Clin Risk Manag 2008; 4: 487-92.
-
Arslanian SA, Lewy V, Danadian K, Saad R. “Metformin therapy in obese adolescents with polycystic ovary sindrome and impaired glucose tolerance: amelioration= of exaggerated adrenal response to adrenocorticotropin with reduction of insulinemia/insulin resistance”. J Clin
-
Endocrinol Metab 2002; 87: 1555-1559.
-
Katulski K, Czyzyk A, Podfigurna A, Genazzani AR, Meczekalski B. “Pregnancy complications in polycystic ovary syndrome patients”. Gynecol Endocrinol= 2015; 31: 87-91.
-
Belli SH, Graffigna MN, Oneto A. “ Effect of rosiglitazone on insulin resistance, growth factor and reproductive disturbances in women with polycystic ovary syndrome”. Fertil Steril 2004; 81: 624-9.
References
Stein IF, Leventhal ML. “Amenorrea associated with bilateral polycystic ovaries”. Am J Obstet Gynecol 1935; 29: 181-191.
Melo AS, Vieira CS, Barbieri MA, RosaE-Silva AC, Silva AA, Cardoso VC, Reis RM, Ferriani RA, Silva-de-Sa MF, & Bettiol H “High prevalence of polycystic ovary syndrome in women born small for gestational age”. Human reproduction 2010; 25: 2124-2131.
Ehrmann DA. “Polycystic ovary sindrome” N Engl J Med 2005; 352: 1223-36.
Diamanti-Kandarakis E, Kandarakis H & Legro RS. “ The role of genes and environment in the etiology of PCOS”. Endocrine 2006; 30: 19-26 .
Gambineri A, Pelusi C, Vicennati V, Pagotto U, Pasquali R. “ Obesity and the polycystic ovary syndrome”. Int J Obes Rel Metab Disord 2002; 26: 883-96.
Von Shoultz B, Calstrom K. “ On the regulation of sex-hormone-binding globulin. A challenge of old dogma and outlines of an alternative mechanism”. J Steroid Biochem 1989; 32: 327-34.
Dunaif A, Green G, Phelp RG. “Acanthosis Nigricans, insulin action and hyperandrogenism: clinical, histological, and biochemical findings”. J Clin Endocrinol Metab 1991; 73: 590-595.
Wild RA, Carmina E, Diamanti-Kandarakis E. “Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the Polycystic Ovary Syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome Society”. J Clin Endocrinol Metab 2010; 95: 2038-2049 .
Hardiman P, Pillay OC, Atiomo W. “Polycystic Ovary Syndrome and endometrial carcinoma”. Lancet 2003; 361: 1810-1812.
Azziz R, Carmina E, Dewailly D. “The androgjen excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report”. Fertil steril 2009; 91: 456-488.
Moran L J, Hutchison SK, Norman RJ, Teede HJ.“ Lifestyle changes in women with polycystic ovary sindrome”. Cochrane Database Syst Rev 2011; 7: CD007506.
Mathur R, Levin O, Azziz R. “Use of ethinylestradiol/drospirenone combination n patients with the polycystic ovary syndrome”. Ther Clin Risk Manag 2008; 4: 487-92.
Arslanian SA, Lewy V, Danadian K, Saad R. “Metformin therapy in obese adolescents with polycystic ovary sindrome and impaired glucose tolerance: amelioration= of exaggerated adrenal response to adrenocorticotropin with reduction of insulinemia/insulin resistance”. J Clin
Endocrinol Metab 2002; 87: 1555-1559.
Katulski K, Czyzyk A, Podfigurna A, Genazzani AR, Meczekalski B. “Pregnancy complications in polycystic ovary syndrome patients”. Gynecol Endocrinol= 2015; 31: 87-91.
Belli SH, Graffigna MN, Oneto A. “ Effect of rosiglitazone on insulin resistance, growth factor and reproductive disturbances in women with polycystic ovary syndrome”. Fertil Steril 2004; 81: 624-9.
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