Use of car-t cells therapy in patients with malignant blood diseases - Review.
DOI:
https://doi.org/10.55312/op.v14i2.4730Abstract
To describe the effectivity the targeted antigen in CAR-T therapy in the treatment of patients with blood malignancies.Keywords:
Chimeric Antigenic Receptor - T (CAR-limfocitet T)., Autologous gene cell therapy., B Cells Antigen CD19 (CD19)., Diffuse Large B Cell Lymphoma (DLBCL)., T Lymphocytes. B Lymphocytes., US Food and Drugs Administration (FDA)., European Medical Agency (EMA)., B cells Non-Hodgkin Lymphoma (NHL)., Acute Lymphoblastic leukemia B (ALL)., CAR-T cells Clinical Trials.Downloads
References
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C.H. June, et al. CAR T cell immunotherapy for human cancer. Science 2018;359(6382):1361-5;doi:10.1126/science.aar6711.
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Salyka Sengsayadeth; Overview of approved CAR‐T therapies, ongoing clinical trials, and its impact on clinical practice. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175669/
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Chimeric agent receptor (CAR) T-Cell therapy. CancerFAx. 2020.https://cancerfax.com/car-t-cell-therapy/.
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FDA approval brings first gene therapy to the United States. U.S. Food Drugs Adm. (2017). https://www.fda.gov/news-events/press-announcements/fda-approval-brings-first-gene-therapy-unitedstates
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FDA Approves Second CAR T-cell Therapy. Cancer Discov.;8(1):5-6. doi:10.1158/2159-8290.CDNB2017-155;
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First two CAR-T cells medicines recommended for approval in the European Medicine Agency. 2017.https://www.ema.europa.eu/en/documents/press-release/first-two-car-t-cells-medicines
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Massimo Fusconi, Andrea Gallo, Armando De Virgilio, Stefania Nataliz. B Lymphocyte Subsets in Patients with Rhinoscleroma. Otolaryngology Head and Neck Surgery 144(5):809-14, February 2011,DOI:10.1177/0194599810396134, Source PubMed
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Alaa Alnefaie, Sarah Albogami, Yousif Asiri, Tanveer Ahmad, Chimeric Antigen Receptor T-Cells: An Overview of Concepts, Applications, Limitations, and Proposed Solutions.
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R.K. Iyer, et al. Industrializing Autologous Adoptive Immunotherapies: Manufacturing Advances and Challenges. Front Med (Lausanne). 2018;5:150;doi: 10.3389/fmed.2018.00150. eCollection 2018.
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E.S. Allen, et al. Autologous lymphapheresis for the production of chimeric antigen receptor T cells. Transfusion. 2017;57(5):1133-41;doi: 10.1111/trf.14003. Frontiers in Bioengineering and Biotechnology. 22 June 2022.https://www.frontiersin.org/articles/10.3389/fbioe.2022.797440/full
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Stephen J. Schuster, M.D; Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma https://www.nejm.org/doi/full/10.1056/nejmoa1804980.
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Jeremy S Abramson; Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study. https://www.thelancet.com/article/S0140-6736(20)31366-0/fulltext
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Emily Whitehead foundation https://emilywhiteheadfoundation.org/news/celebrating-10-years-cancer-free/
References
C.H. June, et al. CAR T cell immunotherapy for human cancer. Science 2018;359(6382):1361-5;doi:10.1126/science.aar6711.
Salyka Sengsayadeth; Overview of approved CAR‐T therapies, ongoing clinical trials, and its impact on clinical practice. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175669/
Chimeric agent receptor (CAR) T-Cell therapy. CancerFAx. 2020.https://cancerfax.com/car-t-cell-therapy/.
FDA approval brings first gene therapy to the United States. U.S. Food Drugs Adm. (2017). https://www.fda.gov/news-events/press-announcements/fda-approval-brings-first-gene-therapy-unitedstates
FDA Approves Second CAR T-cell Therapy. Cancer Discov.;8(1):5-6. doi:10.1158/2159-8290.CDNB2017-155;
First two CAR-T cells medicines recommended for approval in the European Medicine Agency. 2017.https://www.ema.europa.eu/en/documents/press-release/first-two-car-t-cells-medicines
Massimo Fusconi, Andrea Gallo, Armando De Virgilio, Stefania Nataliz. B Lymphocyte Subsets in Patients with Rhinoscleroma. Otolaryngology Head and Neck Surgery 144(5):809-14, February 2011,DOI:10.1177/0194599810396134, Source PubMed
Alaa Alnefaie, Sarah Albogami, Yousif Asiri, Tanveer Ahmad, Chimeric Antigen Receptor T-Cells: An Overview of Concepts, Applications, Limitations, and Proposed Solutions.
R.K. Iyer, et al. Industrializing Autologous Adoptive Immunotherapies: Manufacturing Advances and Challenges. Front Med (Lausanne). 2018;5:150;doi: 10.3389/fmed.2018.00150. eCollection 2018.
E.S. Allen, et al. Autologous lymphapheresis for the production of chimeric antigen receptor T cells. Transfusion. 2017;57(5):1133-41;doi: 10.1111/trf.14003. Frontiers in Bioengineering and Biotechnology. 22 June 2022.https://www.frontiersin.org/articles/10.3389/fbioe.2022.797440/full
Stephen J. Schuster, M.D; Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma https://www.nejm.org/doi/full/10.1056/nejmoa1804980.
Jeremy S Abramson; Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study. https://www.thelancet.com/article/S0140-6736(20)31366-0/fulltext
Emily Whitehead foundation https://emilywhiteheadfoundation.org/news/celebrating-10-years-cancer-free/



