Oksisterolet: Një fushë intensive e kërkimit shkencor
DOI:
https://doi.org/10.55312/op.vi2.4628Abstract
Tashmë pranohet se oksisterolet, produkte të oksidimit të steroleve, luajnë rol themelor në rregullimin e proceseve të ndryshme biologjike, si dhe në zhvillimin e shumë patologjive. Vitet e fundit, kërkues të ndryshëm të fushave të kimisë, të biologjisë dhe mjekësisë janë përfshirë në studime të bashkërenduara, që lidhen me efektet e dobishme të oksisteroleve. Bazuar në literaturën bashkëkohore, në këtë shkrim paraqiten disa të dhëna të reja lidhur me përdorimin e oksisteroleve si mjete potenciale terapeutike.Parole chiave:
oksisterolet, funksionet fiziologjike, strategjitë terapeutike.Downloads
Riferimenti bibliografici
-
Sottero B. et al. Cholesterol oxidation products and disease: an emerging topic of interest in medical chemistry. Current Medical Chemistry 2009; 16: 685-705.
-
Otaegui Arrazola A. et al. Oxysterols: a world to explore. Food Chemical Toxicology 2010; 48: 3289-3303.
-
Schroepfer G. Jr. Oxysterols: modulators of cholesterol metabolism. Physiological Reviews 2000; 80: 361-554.
-
Poli G, Biasi F, Leonarduzzi G. Oxysterols in the pathogenesis of major chronic diseases. Redox Biology 2013;1: 125-130.
-
Iuliano L. Pathways of cholesterol oxidation via non-enzymatic mechanisms. Chemistry and Physics of Lipids 2011; 164: 457-468.
-
Iuliano L. Oxysterols and related sterols in chemistry, biology and medicine: A dynamic European field of investigation. Biochimie 2013; 95: 445-447.
-
Doria M et al. Contribution of cholesterol and oxysterols to the pathophysiology of Parkinson’s disease. Free Radical Biology and Medicine 2016; 101: 393-400.
-
Biasi F et al. Pro-oxidant and proapoptotic effects of cholesterol oxidation products on human colonic epithelial cells. Free Radical Biology
-
and Medicine 2009; 47: 1731-1741.
-
Griffiths WJ et al. New methods of analysis of oxysterols and related compounds by LC-MS. The Journal of Biochemistry and Molecular Biology 2016; 162: 4-26.
-
Grill S, Chow R, Brown AJ. Sterol regulators of cholesterol homeostasis and beyond: the oxysterol hypothesis revisited and revised. Progress in Lipid Research 2008; 47: 391-404.
-
Spann NJ, Glass CK. Sterols and oxysterols in immune cell function. Nature Immunology 2013; 14: 893-900.
-
Traversarri C, Russo V. Control of the immune system by oxysterols and cancer development. Current Opinion in Pharmacology 2012; 12: 729-735.
-
Rutkowska A, Dev KK, Sailer AW. The role of oxysterol/EBI2 pathway in the immune and central nervous system. Current Drug Targets 2016; 17: 1851-60.
-
Hannedouche S. et al. Oxysterol direct immune cell migration via EB12. Nature 2011; 475: 524-527.
-
Fred A. Kummerov. Correlation between cholesterol consumption and heart disease. Clinical Lipidology 2013; 8: 289-294.
-
Brzeska M, Szymczyk K, Szterk A. Current knowledge about Oxysterols: A review. Journal of Food Science 2016; 81: 2299-2308.
-
Calkin AC, Tontonoz P. Liver X receptors signalling pathways and atherosclerosis. Atherosclerosis, Thrombosis and Vascular Biology 2010; 30: 1513-1518.
-
Iguchi et al. Aragusterol A: a potent antitumor marine steroid from the Okinawan sponge. Tetrahedron Letters 1993; 34: 6277-6280.
-
Makoto Ishikawa et al. Neurosteroids and oxisterols as potential therapeutic agents for glaucoma and Alzheimer’s disease. Neuropsychiatry 2018; 8: 344-359.
-
Bjorkhem I. et al. Oxysterols and neurodegenerative diseases. Molecular Aspects of Medicine 2009; 30: 171-179.
-
Guillemont-Legris O, Mutemberezi V, Muccioli GG. Oxysterols in metabolic syndrome: From Bystander molecules to bioactive lipids. Trends in Molecular Medicine 2016; 22: 594-614.
-
Leoni V. et al. Whole body cholesterol metabolism is impaired in Huntington’s disease. Neuroscience Letters 2011;494: 245-249.
-
De Boussac H et al. Oxysterol receptors and their therapeutic applications in cancer conditions. Expert Opinion on Therapeutic Targets 2013; 17: 1029-1038.
-
Johnson J S et al. Novel oxysterols have pro-osteogenic and anti-adipogenic effect in vitro and induce spinal fusion in vivo. Cell Biochemistry 2011; 112: 1673-1684.
-
Montgomery SR et al. A novel osteogenic oxysterol compound for therapeutic development to promote bone growth. Journal of Bone and Mineral Research 2014; 29: 1872-1885.
-
Irundika HK Dias et al. Simvastatin reduces circulating oxysterol levels in men with hypercholesterolaemia. Redox Biology 2018; 16: 139-145.
-
Poirer Johanne et al. Antioxidant supplements improve profiles of hepatic and plasma lipids in butter fed hamster. Nutrition and Metabolic
-
Insights 2010; 3: 1-14.
-
Cirico TL, Omaye ST. Additive or synergetic effects of phenolic compounds on human low density lipoprotein oxidation. Food Chemistry
-
and Toxicology 2006; 44: 510-516.
-
Zern TL et al. Grape polyphenols exert a cardio-protective effect in pre-and postmenopausal women by lowering plasma lipids and reducing oxidative stress. Journal of Nutrition 2005; 135: 1911-1917.
-
Jukka Pekka Soumela. Effect of dietary fat oxidation products and flavonols on lipoprotein oxidation. University of Turku, Finland 2006.
-
Ogino Y et al. Absorbtion of dietary cholesterol oxidation products and their downstream metabolic effects are reduced by dietary apple polyphenols. Lipids 2007; 42: 151-161.
-
Testa Gabriella et al. Loading into nanoparticles improves quercetin’s efficacy in preventing neuroinflamation induced by oxysterols. PLOS One 2014; 9: e 96795.
-
Scientific opinion on dietary reference value for vitamin E as α-tocopherol. EFSA 2015.
-
Iuliano L et al. Bioavailability of vitamin E as function of food intake in healthy subjects. Arteriosclerosis Thrombosis and Vascular Biology 2001; 21: 34-37.
-
Fliesler I S. Antioxidants: the missing key to improved therapeutic intervention in Smith-Lemil-Opitz syndrome?
Riferimenti bibliografici
Sottero B. et al. Cholesterol oxidation products and disease: an emerging topic of interest in medical chemistry. Current Medical Chemistry 2009; 16: 685-705.
Otaegui Arrazola A. et al. Oxysterols: a world to explore. Food Chemical Toxicology 2010; 48: 3289-3303.
Schroepfer G. Jr. Oxysterols: modulators of cholesterol metabolism. Physiological Reviews 2000; 80: 361-554.
Poli G, Biasi F, Leonarduzzi G. Oxysterols in the pathogenesis of major chronic diseases. Redox Biology 2013;1: 125-130.
Iuliano L. Pathways of cholesterol oxidation via non-enzymatic mechanisms. Chemistry and Physics of Lipids 2011; 164: 457-468.
Iuliano L. Oxysterols and related sterols in chemistry, biology and medicine: A dynamic European field of investigation. Biochimie 2013; 95: 445-447.
Doria M et al. Contribution of cholesterol and oxysterols to the pathophysiology of Parkinson’s disease. Free Radical Biology and Medicine 2016; 101: 393-400.
Biasi F et al. Pro-oxidant and proapoptotic effects of cholesterol oxidation products on human colonic epithelial cells. Free Radical Biology
and Medicine 2009; 47: 1731-1741.
Griffiths WJ et al. New methods of analysis of oxysterols and related compounds by LC-MS. The Journal of Biochemistry and Molecular Biology 2016; 162: 4-26.
Grill S, Chow R, Brown AJ. Sterol regulators of cholesterol homeostasis and beyond: the oxysterol hypothesis revisited and revised. Progress in Lipid Research 2008; 47: 391-404.
Spann NJ, Glass CK. Sterols and oxysterols in immune cell function. Nature Immunology 2013; 14: 893-900.
Traversarri C, Russo V. Control of the immune system by oxysterols and cancer development. Current Opinion in Pharmacology 2012; 12: 729-735.
Rutkowska A, Dev KK, Sailer AW. The role of oxysterol/EBI2 pathway in the immune and central nervous system. Current Drug Targets 2016; 17: 1851-60.
Hannedouche S. et al. Oxysterol direct immune cell migration via EB12. Nature 2011; 475: 524-527.
Fred A. Kummerov. Correlation between cholesterol consumption and heart disease. Clinical Lipidology 2013; 8: 289-294.
Brzeska M, Szymczyk K, Szterk A. Current knowledge about Oxysterols: A review. Journal of Food Science 2016; 81: 2299-2308.
Calkin AC, Tontonoz P. Liver X receptors signalling pathways and atherosclerosis. Atherosclerosis, Thrombosis and Vascular Biology 2010; 30: 1513-1518.
Iguchi et al. Aragusterol A: a potent antitumor marine steroid from the Okinawan sponge. Tetrahedron Letters 1993; 34: 6277-6280.
Makoto Ishikawa et al. Neurosteroids and oxisterols as potential therapeutic agents for glaucoma and Alzheimer’s disease. Neuropsychiatry 2018; 8: 344-359.
Bjorkhem I. et al. Oxysterols and neurodegenerative diseases. Molecular Aspects of Medicine 2009; 30: 171-179.
Guillemont-Legris O, Mutemberezi V, Muccioli GG. Oxysterols in metabolic syndrome: From Bystander molecules to bioactive lipids. Trends in Molecular Medicine 2016; 22: 594-614.
Leoni V. et al. Whole body cholesterol metabolism is impaired in Huntington’s disease. Neuroscience Letters 2011;494: 245-249.
De Boussac H et al. Oxysterol receptors and their therapeutic applications in cancer conditions. Expert Opinion on Therapeutic Targets 2013; 17: 1029-1038.
Johnson J S et al. Novel oxysterols have pro-osteogenic and anti-adipogenic effect in vitro and induce spinal fusion in vivo. Cell Biochemistry 2011; 112: 1673-1684.
Montgomery SR et al. A novel osteogenic oxysterol compound for therapeutic development to promote bone growth. Journal of Bone and Mineral Research 2014; 29: 1872-1885.
Irundika HK Dias et al. Simvastatin reduces circulating oxysterol levels in men with hypercholesterolaemia. Redox Biology 2018; 16: 139-145.
Poirer Johanne et al. Antioxidant supplements improve profiles of hepatic and plasma lipids in butter fed hamster. Nutrition and Metabolic
Insights 2010; 3: 1-14.
Cirico TL, Omaye ST. Additive or synergetic effects of phenolic compounds on human low density lipoprotein oxidation. Food Chemistry
and Toxicology 2006; 44: 510-516.
Zern TL et al. Grape polyphenols exert a cardio-protective effect in pre-and postmenopausal women by lowering plasma lipids and reducing oxidative stress. Journal of Nutrition 2005; 135: 1911-1917.
Jukka Pekka Soumela. Effect of dietary fat oxidation products and flavonols on lipoprotein oxidation. University of Turku, Finland 2006.
Ogino Y et al. Absorbtion of dietary cholesterol oxidation products and their downstream metabolic effects are reduced by dietary apple polyphenols. Lipids 2007; 42: 151-161.
Testa Gabriella et al. Loading into nanoparticles improves quercetin’s efficacy in preventing neuroinflamation induced by oxysterols. PLOS One 2014; 9: e 96795.
Scientific opinion on dietary reference value for vitamin E as α-tocopherol. EFSA 2015.
Iuliano L et al. Bioavailability of vitamin E as function of food intake in healthy subjects. Arteriosclerosis Thrombosis and Vascular Biology 2001; 21: 34-37.
Fliesler I S. Antioxidants: the missing key to improved therapeutic intervention in Smith-Lemil-Opitz syndrome?



